Kutshanje, izigebenga ezibini eziphambili zecuba, i-PMI kunye ne-BAT, ngokulandelelanayo zipapashe amaphepha ophando kwiijenali zezonyango eziphambili zamazwe ngamazwe.Iziphumo zophando zibonisa ukuba iimveliso ezintsha zecuba ezifana ne-e-cigarettes kunye ne-heat-non-burn-non-burns aziyingozi kakhulu kwaye zinetyhefu kune-cigarettes yendabuko, kwaye inokunciphisa kakhulu impembelelo kwinkqubo yokuphefumula.umonakalo.
Njengoko ulwazi lwabantu malunga neengozi zokutshaya lusiya lusiba nzulu, i-e-cigarettes iya iqatshelwa ngakumbi njengento ethatha indawo yecuba, kodwa iziphumo zexesha elide ze-flavour ye-e-cigarette flavour mixs kunye nomsi wecigarette kubantu abatshayayo zisaza kuphononongwa ngakumbi.Kungekudala, u-PMI uPhilip Morris International upapashe ingxelo yophando "Uvavanyo lwe-inhalation toxicity yomsi wecuba kunye ne-aerosols evela kumxube we-flavour: isifundo se-5-iveki kwi-A / J iigundane" kwiBritish Journal ye-Toxicology "Journal of Applied Toxicolog", ichaza iinkcukacha. yezihloko ezinxulumene Amanyathelo ophando kunye neziphumo.
Kuvavanyo, iimpuku zamadoda angama-87 kunye neempuku eziyi-174 ezizii-nulliparous nezikhulelweyo zabelwa ngokungacwangciswanga kumaqela ovavanyo ayi-9, kwaye zavavanywa emoyeni, umsi wecuba, kunye ne-e-cigarette aerosols ezinemigxina emithathu eyahlukeneyo yencasa, ephezulu, ephakathi, kwaye ephantsi. .Ukuvezwa ukuya kuthi ga kwiiyure ezi-6 ngosuku, iintsuku ezi-5 ngeveki, kwiiveki ezi-5 kulandelwa yi-necropsy, ubunzima bomzimba kunye novavanyo lwe-histopathological.
Iziphumo zokugqibela zovavanyo zibonise ukuba xa kuthelekiswa nokuvezwa komsi wecuba, iigundane ezivezwe kwi-e-cigarette aerosols kunye nangaphandle kwe-flavour azikho utshintsho olubalulekileyo kwizitho zokuphefumula, impumlo, kunye nezicubu ze-laryngeal epithelial, ezibonisa ukuba i-e-cigarettes I-sol ayicaphuki kakhulu. kwizicubu ezihambelanayo kunye namalungu.Iziphumo zovavanyo ziphinde zangqina ukuba, xa kuthelekiswa necuba zesintu, i-e-cigarettes inokunciphisa kakhulu ukudumba kwemiphunga, kunye nomonakalo kwi-epithelium yempumlo, umqala kunye noqhoqhoqho.
I-BAT yaseBritani yaseMelika iTobacco yapapasha iphepha lophando elinesihloko esithi "Uvavanyo loVavanyo kunye neNdlela ye-Vitro yokuya kwiBridge phakathi kweentlobo ezahlukeneyo zeemveliso zecuba ezifudumalayo" kwi "Igalelo kwiCuba kunye noPhando lweNicotine" kwijenali yesayensi, kwaye yenza uphando kwi-THP (imveliso ye-HNB) I-Toxicology. uvavanyo.Kuvavanyo, i-aerosol kunye nomsi wecuba ohlukeneyo ezintlanu ze-THP kunye ne-THP enye esisiseko zasetyenziswa njengendawo yovavanyo, kwaye i-cytotoxicity yavavanywa ngokusebenza kweeseli ze-epithelial zemiphunga yomntu.Iziphumo zibonise ukuba zonke iimpendulo ze-cytotoxic kwiqela le-THP bezimalunga nama-95% ngaphantsi kunezo zeqela lomsi wecuba, kwaye akukho mahluko ubalulekileyo kwityhefu phakathi kwe-THP ezintlanu ezahlukeneyo kunye ne-THP esisiseko.
Uphononongo lugqibe ekubeni uphuhliso kunye nonikezelo lwezinye icuba kunye neemveliso inikotini zikhula ngokukhawuleza, abathengi baya besanda ukwamkela iimveliso ezintsha ezifana ne-THP, kunye nokhuseleko kunye nobungozi bayo njengenxalenye yovavanyo lwe-toxicological lufanelekile ingqalelo kushishino.Kuphela xa imveliso ihlangabezana nemigangatho (kubandakanywa nokusebenza kwebhetri) inokudlala ngcono indima yayo njengesicwangciso sempilo yoluntu.
IiReferensi:
Ee Tsin Wong,Karsta Luettich,Lydia Cammack,et al.Uvavanyo lwetyhefu yokuphefumla yomsi wecuba kunye ne-aerosols evela kwimixube yencasa: Uphononongo lweeveki ezi-5 kwiimpuku ze-A/J.Ijenali ye-toxicology esetyenzisiweyo, ngo-2022
UTomasz Jaunky, uDavid Thorne, uAndrew Baxter, et al.Indlela yoVavanyo yoVavanyo kunye ne-In Vitro yokuya kwibhulorho phakathi kweentlobo ezahlukeneyo zeemveliso zecuba ezishushu.Amagalelo kuPhando lweCuba kunye neNicotine, ngo-2022.
Ixesha lokuposa: Feb-01-2023
